State law addresses vaccinations.
South Carolina Code of Laws 44-29-180. School pupils and day care center children to be vaccinated or immunized; department to monitor immunization records of children in day care; exemptions and exclusions.
(A) No superintendent of an institution of learning, no school board or principal of a school, and no owner or operator of a public or private childcare facility as defined in Section 63-13-20 may admit as a pupil or enroll or retain a child or person who cannot produce satisfactory evidence of having been vaccinated or immunized so often as directed by the Department of Health and Environmental Control. Records of vaccinations or immunizations must be maintained by the institution, school, or day care facility to which the child or person has been admitted.
South Carolina Code of State Regulations 61–8. Immunization Requirements for School and Childcare Attendance
A. No child or person shall be admitted to or retained in any public, private, or parochial school, grades kindergarten through twelve (K-12), or any public or private childcare facility as defined in Code Section 63-13-20 without a valid South Carolina Certificate of Immunization. To be valid, the South Carolina Certificate of Immunization must be signed by a licensed physician or his/her authorized representative. Exemptions to this requirement are authorized in Section II of this regulation. B. A South Carolina Certificate of Immunization must be presented to school or childcare officials on admission and as required to document any subsequent immunizations required by the Department. School and childcare officials shall keep a copy of the Certificate with the child's or person's record.